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Omega-3s and Blood Pressure

Arm with blood pressure machine
Highlights
  • Elevated blood pressure is the most common preventable risk factor for cardiovascular disease
  • Blood pressure becomes elevated when the cells and structures of the arteries become compromised
  • Marine sources of omega-3 fatty acids have been shown to help support a healthy range of blood pressure via their effects on the cells and structures of the artery

Elevated blood pressure often has no symptoms

What comes to mind when you hear “high blood pressure”? A stressed-out, red-faced businessman with a blood vessel throbbing in his forehead? The truth is, even when blood pressure becomes elevated, it typically doesn’t have any recognizable symptoms. In fact, fewer than 50% of people with elevated blood pressure are even aware that they have it.1 Plus, blood pressure usually increases naturally with age regardless of stress levels,1 an inconvenient fact for those who’ve spent their lives never having to think about it.

Blood pressure can offer an early indication of bigger health issues

But why should you care about your blood pressure anyway? Why does the doctor always measure it, even if you’re there to see them about something totally unrelated? It’s because doctors know (and soon you will too) that blood pressure provides an early indication of issues involving your heart, arteries, and organs due to cardiovascular disease. Elevated blood pressure is not only a preventable risk factor for cardiovascular disease (heart attack, stroke, peripheral artery disease, and others), but also for chronic kidney disease and cognitive impairment.1

Understanding what blood pressure is and how it becomes elevated are important, but you also need to know what you can do to keep it healthy. As you will learn, omega-3 fatty acids from marine sources have been shown, in no less than 78 clinical trials over the last 35 years, to help support healthy blood pressure.29

Arteries affect blood pressure through vasodilation and vasoconstriction

Arteries, such as the aorta, are composed of three basic layers. The tunica adventitia is the outermost layer (and isn’t involved in blood pressure). The tunica media is the middle layer, and is composed of alternating layers of muscle and structural fibers. There are two types of structural fibers, elastin and collagen.10 Elastin provides the distensible, or flexible, properties of arteries, while collagen provides stiffness.10 The tunica intima includes the endothelium, a single layer of cells that makes direct contact with the blood.

One of the main functions of the endothelium is to promote widening, or dilation, of blood vessels (vasodilation). For example, in response to increased blood flow (such as when your heart beats faster), the cells of the endothelium cause the blood vessel to dilate.11 Vasodilation happens because faster blood flow across the endothelial cells causes them to produce a tiny gas molecule called nitric oxide. Nitric oxide then travels into the middle (tunica media) of the blood vessel and causes the muscle layer to relax.11

Once the blood flow decreases again, the blood vessel constricts (vasoconstriction). Importantly, the ability of blood vessels, especially arteries, to dilate and constrict in response to blood flow allows your blood pressure to remain within a healthy range.

Let’s take a second to think about the implications of what we’ve learned so far by asking two questions:

1. What would happen if your artery was so stiff that it was unable to dilate when blood flow increases?

It would act like a garden hose—since the hose doesn’t expand, the more water going through increases the pressure of that water. Thus, your blood pressure would increase.

2. What would happen if the endothelial cells lining the artery couldn’t produce nitric oxide in response to increased blood flow? 

Your artery would have a hard time expanding to accommodate more blood, and your blood pressure would increase. 

As you will learn next, stiff arteries and decreased production of nitric oxide are two of the primary ways by which chronically elevated blood pressure occurs. 

What causes elevated blood pressure?

While the causes of elevated blood pressure are complex and not completely understood, there are two processes known to be involved: endothelial dysfunction and arteriosclerosis. Both of these processes are strongly associated with the classic cardiovascular risk factors, such as smoking and obesity. In fact, both endothelial dysfunction and arteriosclerosis significantly predict the development of cardiovascular disease, independently of other risk factors.1215

Endothelial dysfunction

Endothelial dysfunction basically means that the endothelial cells of the artery (described earlier) don’t function normally. Specifically, the cells don’t produce enough nitric oxide to dilate blood vessels.14 Without sufficient production of nitric oxide, the balance between vasodilation and vasoconstriction is disrupted, resulting in a greater tendency toward vasoconstriction (i.e., increased blood pressure).11

One of the proposed causes of endothelial dysfunction is oxidative stress, which occurs when the abundance of pro-oxidative molecules is greater than the abundance of antioxidant molecules. Pro-oxidative molecules include reactive oxygen species (ROS), which damage important molecules like DNA and enzymes. ROS are normally produced throughout the body, and have important functions within blood vessels themselves.11 However, excessive ROS decreases the availability of nitric oxide, and may use nitric oxide to form molecules that are potentially toxic to cells.16 In addition to decreasing the production of nitric oxide,11 oxidative stress can actually cause the endothelial cells to produce ROS instead!16

Arteriosclerosis

With age, our arteries lose their elastic properties and become stiff. This ‘hardening’ of the arteries is called arteriosclerosis. During this process, the layers of elastin in the tunica media degrade and are replaced by collagen.14 The replacement of elastin with collagen in arteries is a problem because collagen cannot bear physical loads like elastin does. As load-bearing components are lost, blood pressure increases.17 This elevation in blood pressure sets in motion a vicious cycle of further breakdown of elastin, deterioration of the vessel wall, and higher blood pressure.14

Research indicates regular intake of omega-3s supports a healthy range of blood pressure

Over the last 35 years, omega-3 fatty acids from marine sources have been studied in numerous high-quality clinical trials for their role in supporting a healthy blood pressure.29 Omega-3s from marine sources (called EPA and DHA), as opposed to plant sources, are particularly important because these are the omega-3 fats that actually have biological activity. (Please see “Is eating chia and flax enough to meet your daily omega-3 needs?” to understand the difference between plant and marine sources of omega-3s.) 

Importantly, increasing one’s dietary intake of EPA and DHA from marine sources has been shown to support healthy blood pressure.18 These sources include fatty fish and seafood (e.g., salmon, tuna, sardines), or purified oils from fish or algae.  Further, improvements in blood pressure are associated with elevated omega-3 biomarkers.1820 This means that, with a simple blood test obtained through your physician, you can track your nutrient sufficiency of EPA and DHA to know whether you’re consuming enough marine sources to support healthy blood pressure. (Please see “Omega-3 Dosage: How much EPA and DHA should I take?”)

EPA and DHA support blood pressure through multiple mechanisms

Unsurprisingly, given their involvement in cellular structure and cell signaling, there seem to be multiple mechanisms by which EPA and DHA support healthy blood pressure. These fatty acids are incorporated into the phospholipid membrane of every cell in the body, where they influence how the cell responds to its environment. Specifically, the extensive double-bonded structure of EPA and DHA imparts much needed fluidity to the membrane. Membrane fluidity is critical for the formation of appropriate molecular complexes that facilitate communication between the cell’s external and internal environments. 

EPA and DHA affect the production of nitric oxide

Importantly, EPA and DHA can also directly affect the production of nitric oxide when incorporated into endothelial cell membranes.14, 2124 There are many cell culture and animal studies which indicate that omega-3 fatty acids can increase production of nitric oxide from the endothelium, by affecting molecular complexes and gene expression.22, 2426

EPA and DHA help reduce oxidative stress

In addition to their effects on cell membranes, EPA and DHA also help address inflammation.27 Oxidative stress and the production of ROS are normal aspects of the inflammatory process; however, these reactions become damaging when inflammation is ongoing. Fortunately, EPA and DHA can help address inflammation by producing special molecules (low-affinity eicosanoids) that interfere with inflammatory processes. These omega-3s also decrease gene expression of inflammatory molecules,28 which has the effect of reducing production of ROS.14,29 As EPA and DHA diminish oxidative stress, production of nitric oxide is restored.30,31

Speak to your doctor about whether omega-3 supplementation is right for you

In addition to being easily accessible, blood pressure is perhaps the most critical and actionable indicator of current and future cardiovascular health.1 And importantly, because blood pressure almost inevitably increases with age, even those in seemingly perfect health may need support maintaining a healthy blood pressure at some point. Fortunately, research indicates that the regular intake of marine sources of omega-3 fatty acids can help promote and protect the dynamic functions of your vascular cells, which can in turn support a healthy blood pressure. We encourage you to speak with your physician about whether EPA and DHA supplementation is right for you, particularly if you have a diagnosis of high blood pressure (hypertension). 

Sharon Matheny, PhD is Manager of Nutrition Science Communications for Nordic Naturals. She holds a doctorate in Cell and Molecular Biology, with specializations in cancer cell signaling and molecular neuroscience. After a career in biotechnology developing molecular diagnostics, she has found her calling in bringing evidence-based nutrition and health science information to the general public and health professionals.

Arteriosclerosis: The thickening, hardening, and loss of elasticity of the walls of arteries.

Collagen: A structural protein that provides strength and structure to bones, muscles, skin, and tendons.

DHA: A polyunsaturated fatty acid that belongs to the omega-3 family and plays structural and functional roles in cells throughout the body, particularly the eye and brain.

Elastin: A structural protein that provides resilience and elasticity to tissues and organs.

Endothelial dysfunction: When endothelial cells of the artery do not produce enough nitric oxide to function normally.

Endothelium: A single layer of cells that line the interior surface of blood vessels and make direct contact with the blood.

EPA: A polyunsaturated fatty acid that belongs to the omega-3 family and plays structural and functional roles in cells throughout the body.

Nitric oxide: A gas molecule that relaxes the inner muscles of the blood vessels, causing them to widen and increase circulation.

Phospholipid membranes: A central feature of living cells that serves as a physical boundary for the cell and its intracellular contents, and also provides a platform for proteins to bind and interact with each other.

Oxidative stress: An imbalance of free radicals (pro-oxidative molecules) and antioxidant molecules in the body, which can lead to cell and tissue damage.

Reactive oxygen species: A type of unstable molecule that contains oxygen and that easily reacts with other molecules in a cell.

Vasoconstriction: Narrowing of the blood vessels that results from contraction of the muscular walls of the vessels.

Vasodilation: Widening (or dilation) of blood vessels that results from relaxation of the muscular walls of the vessels.

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